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A two-year field study was conducted in saffron fields to assess whether herbicides and fertilizers could be sprayed simultaneously in early growth stage of the weeds at Agricultural and Natural Resources Research and Education Center of Mashhad, Khorasan-Razavi province, Iran, in 2018-2020 growing seasons. The layout was a completely randomized block design in three replications. Foliar application of fertilizers in saffron (which suffering from the lacking of the active root systems in late winter and early spring) is exactly overlaps the best time to spray herbicides to control weeds in saffron fields, then makes it important to know whether they can be mixed together in one spray tank. Treatments were consisted of five herbicides: haloxyfop methyl (1 l/ha), sethoxydim (2 l/ha), atrazine (1 kg/ha), bentazon (3 l/ha), oxyflourfen (2 l/ha) and five fertilizers were including: NPK (20%, 20%, 20%) + micro nutrients, NPK (4%, 8%, 12%) + micro nutrients (specifically formulated for saffron), Zn-EDTA (15%), Fe-EDTA (13.2%) and free amino acids (20% w/w). Bromus tecturum, Triticum boeoticum and Poa trivialis were dominant grass weeds and Acroptylon repense and Cirsium arvense were dominant broadleaved weed species. No sedimentation or chemical incompatibilities were observed in tank mixed solutions. Measurements of pH values revealed that bentazon (pH=8.78) was the most basic and sethoxydim (pH=6.14) was the most acidic herbicides and NPK (4%, 8%, 12%) + micro nutrients (specifically formulated for saffron) (pH=4.55) and Fe-EDTA (13.2%) (pH=5.73) were the most acidic fertilizers. Herbicides whether sprayed individually (by 24 h interval with foliar application of fertilizers) or tank mixed with fertilizers, well controlled target weeds in both years. No significant differences in weed control rate observed between individual or mixed application of herbicides and fertilizers. No saffron injury observed in mixed application of herbicides and fertilizers and therefore, their tank mixed application are seems to be safe enough to be sprayed on saffron fields.